Particle Replication in Non-Wetting Templates (PRINT) is a platform particle drug delivery technology that coopts the precision\r\nand nanoscale spatial resolution inherently afforded by lithographic techniques derived from the microelectronics industry to\r\nproduce precisely engineered particles. We describe the utility of PRINT technology as a strategy for formulation and delivery\r\nof small molecule and biologic therapeutics, highlighting previous studies where particle size, shape, and chemistry have been\r\nused to enhance systemic particle distribution properties. In addition, we introduce the application of PRINT technology towards\r\nrespiratory drug delivery, a particular interest due to the pharmaceutical need for increased control over dry powder characteristics\r\nto improve drug delivery and therapeutic indices. To this end, we have produced dry powder particles with micro- and nanoscale\r\ngeometric features and composed of small molecule and protein therapeutics. Aerosols generated from these particles show\r\nattractive properties for efficient pulmonary delivery and differential respiratory deposition characteristics based on particle\r\ngeometry. This work highlights the advantages of adopting proven microfabrication techniques in achieving unprecedented control\r\nover particle geometric design for drug delivery.
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